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What is GMP?

You’ve likely seen ‘GMP’ on a Phenyketonuria (PKU) or Tyrosinemia formula label or heard about it through your dietitian. But what exactly is it and why is it getting so popular?GMP can be used as a protein source for PKU and Tyrosinemia formulas. GMP, short for glycomacropeptide, is a peptide – a type of short protein. Peptides typically consist of shorter chains of amino acids, whereas true proteins are larger and more complex structures.

GMP is a byproduct of the cheesemaking process. Cheese is made from milk and contains intact protein. Milk consists of two types of proteins: casein and whey. During the cheese making process, the whey is separated from the casein; the casein part is what is used for cheese, the whey part is used for other purposes. GMP is found in the whey portion and must be filtered out to be used as an ingredient in formulas.

Contrary to other proteins, pure GMP does not contain phenylalanine (PHE), tyrosine (TYR) and a couple of other amino acids. That’s why it is a suitable protein source for PKU and Tyrosinemia formulas. However, through the process of isolating GMP from the whey part of the milk, some very small amounts of PHE and TYR cannot be filtered from the actual GMP and are part of the GMP ingredient used in PKU and Tyrosinemia formulas.

GMP by itself lacks certain amino acids that are important for growth and development. These amino acids must be added to the formulas so that PKU and TYR formulas are appropriate for individuals with PKU or Tyrosinemia. That’s why you see GMP and free amino acids listed as ingredients on your PKU and Tyrosinemia formula label.

You may have noticed slight variations in the PHE content when comparing GMP formulas (for example, between 10‐18 mg PHE per 10 g protein equivalent). Healthcare professionals have told us, that the differences are so small that they are clinically not relevant, and studies support this. This means that if a GMP‐based product is appropriate for someone with PKU or Tyrosinemia, the slight differences in PHE content are not important.

GMP is still a growing concept, but several studies support that GMP‐based products are safe and appropriate for most individuals with PKU or Tyrosinemia. GMP‐based products have a milder taste, and that milder taste is often preferred over amino acid‐based products. Finding a formula you or your child like is very important as that can certainly help with diet adherence. In addition, a small number of studies also report that patients feel fuller when consuming a GMP‐based formula.

A small number of clinical studies are also looking into other benefits of GMP‐based products in metabolics. However, the results of these studies are inconclusive. More research is needed to provide definite answers.

For some people with PKU or Tyrosinemia, the amount of PHE in GMP‐based formulas may be too high. Rest assured that formulas that are based 100% on amino acids (with no GMP) provide you or your child with all the nutrients needed for proper growth and development, including important vitamins and minerals for bone health. But of course, your dietitian can advise you on which formula is best for you or your child.

Want to find a GMP‐based formula? You’ve come to the right place!

Check out the variety of GMP‐based formulas that Nutricia has to offer: click on a product above  and read our blog on GMP‐based products from Nutricia.  READ NOW

Always talk to your dietitian before making any diet changes – and contact us if you have any questions about metabolic formulas. Visit www.MedicalFood.com for more information.

Written by: Ulrike Reichert, MS

Director Medical Affairs Keto/Metabolics Nutricia North America

 

 

PhenylAde GMP READY, PhenylAde GMP Drink Mix, and PhenylAde GMP Mix-In are medical foods for the dietary managment of proven Phenylketonuria (PKU) and must be used under medical supervision.  TYR Lophlex LQ is a medical food for the dietary management of proven Tyrosinemia  and must be used under medical supervision. 

 

Are you READY?

Are you READY?

New at Nutricia is PhenylAde® GMP READY, a ready‐to‐ drink PKU formula, providing 10 g protein equivalent and 110 kcal in one drink box (8.5 fl oz). It is also the only GMP‐ based formula with both DHA and EPA, two important omega‐3 fatty acids missing in the PKU diet.

PhenylAde GMP READY:

  • Offers an enjoyable, neutral flavor with a smooth texture for easy drinking

  • Contains GMP, which is made from an intact protein source and is naturally low in phenylalanine.   Click HERE to learn more about GMP.

  • Provides an excellent source of both calcium and vitamin D, two nutrients that help build and maintain strong bones and teeth

A ready‐to‐drink formula can make your life so much easier: from grabbing it in the morning for your breakfast drink to throwing it in the lunch bag for school or work or when you travel. We all have busy lives, and PhenylAde GMP READY is here to provide great nutrition in a convenient drink box.

Take the taste challenge as some of your fellow PKUers have done and let us know your thoughts!

GET READY TODAY!

Always talk to your dietitian before making any diet changes – and contact us if you have any questions about metabolic formulas. Visit MedicalFood.com for more information.

Your Nutricia Metabolics Team

 

 

 

PhenylAde GMP READY is a medical food for the dietary management of proven Phenylketonuria (PKU) and must be used under medical supervision.

Loprofin Pasta and the delicious taste of Italy

Ever wonder where Loprofin Pasta is made?

Meet Lorenzo Mennucci. The Mennucci family began making Loprofin Pasta almost 50 years ago in Tuscany. It is now in its fifth generation and is managed by Lorenzo Mennucci. In 1877, Giuseppe Mennucci started making pasta in a small grocery store in the countryside of Tuscany. At that time, the process of making and drying the pasta was carried out in the courtyard under the sun. This all nearly ended during the Second World War, when the company was bombed and partially destroyed. After the bombing, the Mennucci family was quick to rebuild the factory. During the rebuilding process, all pasta machines that were not destroyed were moved into local homes near Tuscany to maintain the production of pasta.

The Mennucci family are very passionate about using the highest quality of ingredients which are mainly sourced from Italy. There are only four ingredients in low protein pasta which are mainly starches; corn, potato, rice and coloring (annatto). Lorenzo believes that when there are so few ingredients in a product it is important that you use the highest quality of ingredients.

The main difference in the production of low protein pasta and ordinary pasta is that gluten is the protein that binds the dough in ordinary pasta. For low protein pasta, steam is used instead to bind the starches together to make a dough. Low Protein Pasta is made using spring water that comes from the Tuscan mountains.

See for yourself where our Loprofin Pastas are made in this video  of the Mennucci family!

View recipes made with Loprofin Low Protein Pasta at MedicalFood.com/Recipes 

Making the Most of Your Meal

Satisfaction from food or a meal is something everyone wants. Although many foods may be restricted or limited on a low protein diet, you do not have to compromise taste. Selecting the  foods you eat involves a variety of factors. We choose foods based on taste and smell, in addition to texture, sight and culture.

To make the most of your meal, begin by identifying what you crave, like spicy, sweet, crunchy or salty. This will make your meal more satisfying.Here are some tips to help you make the most of your meal.

  • Spicy: Add seasonings that can add a kick. For example, add cracked pepper, crushed red pepper or hot sauce to steamed vegetables to give a familiar item a new twist.

  • Sweet & Tangy:  Satisfy your sweet and tangy craving with grilled pineapple topped with BBQ sauce on a low protein bun. You can also add mandarin oranges and Italian dressing to a garden salad for added flavor and tang.

  • Crunchy: With a little creativity you can add a snap to any dish. Make your own salad iStock_000015639017Mediumcroutons with low protein bread. Season them in a variety of ways by using garlic powder, cayenne pepper or Italian herbs depending on your personal desire for savory or spice. Another great way to add crunch is to include raw vegetables, like cucumbers or carrots slices to a salad or sandwich.

  • Salty: Salt is among the most popular taste craving. Although highly desired, salt is an ingredient to be used in moderation. A little bit goes a long way. To satisfy your craving for salt, try slicing fresh potatoes very thin and sprinkling with garlic and a touch of sea salt. Bake them until crisp for a satisfying addition to your meal or snack.  

  • Smooth and Creamy: Create your own creamy low protein dip with your favorite seasonings for a flavorful way to enjoy Low Protein Crackers or fresh cut vegetables. You can also include a sweet treat at the end of your meal to help satisfy your need for something smooth and creamy.

Your Guide to Getting Back on the PKU Diet

PKU is Diet-for-Life.  It’s Never Too Late to go back on diet.  

   Book Cover

Request a free copy of this helpful booklet “Your Guide to Getting Back on the PKU diet” and help yourself or someone you love get re-started on the PKU diet today!

This book contains:

  • Facts and Myths about the PKU and the diet

  • Tips for making formula part of your life again

  • Top 10 Nutricia PKU formulas for adults

  • Contact information to find a clinic and get re-started on diet

  • Inspiring quotes for PKU adults and more…

PKU Q&A
Tips for Making PKU Formula part of your life (1)

 

Top 10 PKU Formulas for Adults

REQUEST YOUR COPY

How does PhenylAde GMP taste? Ask David.

 

My name is David Harris. I’m 40 years old and I was diagnosed with classical PKU.

When I tasted the PhenylAde GMP product, it was very easy to drink, it was very smooth, and in comparison to other products in the market, I actually preferred it.

Formula taste is key. It’s very important, because without a good taste, and a good consistency; it’s very difficult to get down.

If it tastes good, then I’ll drink it.


Curious to try PhenylAde GMP?

GMP_SAMPLE_button

Amino Acid Blends

Ever wish you could just make your own formula using your favorite great tasting drink?

Well, now you can with Nutricia’s Amino Acid Blends.

This type of formula is available for PKU (PhenylAde™ Amino Acid Blend), MSUD (Complex MSD Amino Acid Blend) and GA-1 (GlutarAde™Amino Acid Blend).

Create Your Own PKU Formula with PhenylAde MTE Amino Acid Blend

PhenylAde™ MTE Amino Acid Blend for PKU

It’s simple, this style of medical food is just the amino acid (protein) part of your formula . It is virtually tasteless and ordorless. You simply MIX-IT-IN to the drink of your choice.

Seriously, it is that easy. So, yes wishes can come true!

Example:

Love drinking sports drink while you exercise or play soccer?

Why not turn that sports drink into your PKU formula and get some post workout phenyalanine-free (for PKU) protein at the same time.

Other examples:

Mix  with lemonade, iced tea, fruit punch, orange drink or anything you think it would taste good with.

There are no rules, expect you want the drink you choose to be protein-free or very, very low in in protein. You can even mix Amino Acid Blend into ready to eat foods like applesauce and tomato sauce.

Mix-It-In---Convenience-Store

Lastly, if you or your child love your current formula but have a hard time with that last serving to meet your full daily diet prescription.

Talk to your metabolic healthcare professional about adding a scoop of Amino Acid Blend to increase the medical food protein content without adding volume.

For more information about PhenylAde Amino Acid Blend (for PKU), Complex MSD Amino Acid Blend (for MSUD) or GlutarAde GA-1 Amino Acid Blend (for GA-1) visit www.Medicalfood.com or 800-605-0410 to request a sample.

 

Please note:  PhenylAde Amino Acid Blend, Complex MSD Amino Acid Blend and GlutarAde GA-1Amino Acid Blend are medical foods intened for use under medical supervision.  Please consult a metabolic healthcare professional prior to making any changes to your metabolic diet. 
PhenylAde & GlutarAde are trademarks of Nutricia North America.

Posted by: Sandy Simons, MA, RD, CHES

Sandy is a Registered Dietitian and Certified Health Education Specialist. She received her graduate training at Columbia University’s Teacher College in New York. She has been working on the industry side of metabolic nutrition for the past 12 years and is often seen at patient events around the country.

Why can’t I just follow a low protein diet?

The simplest answer is because you need protein.  Following a low protein diet without formula could lead to protein deficiency. You may also lack energy and develop an array of secondary health problems.

PKU formula  provides phenylalanine-free protein.  Since all natural food, with the exception of pure fat and sugar, contain some PHE, you must watch your total food intake. If you only eat foods that are low in protein you body may not get enought daily protein.  In addition, eating larger portions of foods that are ‘lower’ in protein can still add up to up more phenylalanine than you can tolerate in a day, resulting in high blood PHE levels.

Formula allows you to take in PHE-free protein and calories to help you meet your daily needs.   PKU formula can also help you feel less hungry.   Controling hunger is important becasue despite your best efforts to only eat low protein, excess hunger may lead you to consume some foods that are higher in protein or larger portions.

Don’t forget – drinking PKU formula also provides a balance of all the other amino acids (building blocks of protein) you need plus tyrosine which is an essential amino acid (needed from food) for those with PKU.

If you are currently not drinking formula and only watching what you eat, assess the reasons why you are not going ‘all in’ on your PKU diet.

  • Are you uncertain if your insurance covers formula or have you been denied in the past?
  • Do you recall from childhood hating your formula and not wanting to drink it?
  • Just stopped re-ordering for no good reason at all?

If any of these ring a bell, let Nutricia help you.

We offer a complimentary samples and a staff of trained coverage specialist that can help navigate your insurance to see if you have coverage and help find a local supplier.

Don’t delay – getting back on track and including PKU formula in your diet will be one decision you will not regret.

Request a free PKU product sample at www.medicalfood.com


Posted by: Sandy Simons, MA, RD, CHES

Sandy is a Registered Dietitian and Certified Health Education Specialist. She received her graduate training at Columbia University’s Teacher College in New York. She has been working on the industry side of metabolic nutrition for the past 11 years and is often seen at patient events around the country. This post is based on an excerpt from My PKU Toolkit: A Transition Guide to Adult PKU Management.

Metabolic Disorders – Talking to your young child

What to say to your child

While your child is not old enough to manage their metabolic disorder alone, it is valuable for them to begin to better understand their diet and treatment. When speaking with your child about their metabolic disorder, the following tips may be helpful:

  • Use simple examples to explain ideas
    For example, when explaining to your child why their metabolic diet is important, it may be helpful to relate the diet to that of a food allergy. Speak with your metabolic team who will also have information about books to read to your child to help him or her understand special diets.
  • Let your child know they can say “no”
    If you haven’t already, teach your child to ask you before eating unfamiliar foods, and that it is OK to say no to anyone who offers food that is unfamiliar or off limits.
  • Tell your child it isn’t his or her fault
    A child may not understand why he or she has metabolic disorder when others do not, and may think that he or she did something to ‘deserve’ it. Explain to your child that everyone is born with different qualities, such as hair and eye color, and a metabolic disorder is something that people are born with, not something that anyone causes. Reinforce to your child that he or she is special, and that this special way of eating is to keep him or her healthy.
  • Stay positive.
    Sending the right message about foods and treatment is important. It is better to talk about off-limit foods as “high-protein,” “no,” “red” or “stop” foods rather than “bad” or “naughty” foods. Help your child accept and manage their metabolic disorder as he or she grows. Never say anything negative about the food or formula to your child. This special way of eating is to keep him or her healthy.
  • You’re not alone
    Talk to your child about other people you know who are on a special diet, even if they are adults, so your child knows that he or she is not the only one on a special diet.   Get involved!   Go to a local metabolic or National event.

Click here to view upcoming events and metabolic support groups across the nation.

 

*Reference Source:Adapted from – My PKU Binder. National PKU Alliance. Chapter 5: Ages 3 to 6 Years, Page 41.

New Artificial Sweeter – OK for PKU?

FDA Approves New Artificial Sweetener

A new sugar substitute called advantame was approved on Monday by the U.S. Food and Drug Administration.  Advantame is chemically similar to aspartame (Equal), and certain people should avoid or limit their use of aspartame, the FDA noted.

These people have a genetic disorder called phenylketonuria (PKU), which makes it difficult for them to metabolize phenylalanine, a component of both aspartame and advantame. Food with aspartame must include label information warning people with PKU about the presence of phenylalanine.

The FDA evaluated whether advantame should also carry alerts for people with PKU. Because advantame is much sweeter than aspartame, only a small amount is needed to achieve the same level of sweetness.  As a result, foods that contain advantame do not need to include alerts for people with PKU, the FDA said.

Be sure to talk to your metabolic professional if they feel advantame is suitable for your diet.  Currently, the exact PHE content has not been reported.

SOURCE: U.S. Food and Drug Administration, news releases, May 19, 2014